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Nalidixic acid had adequate activity against Gram-negative aerobes, but its modest serum and tissue concentrations coupled with its relatively high minimal inhibitory concentrations (MICs) precluded its use to treat systemic infections.

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According to an evaluation of the dosing regimen incorporated by the Food and Drug Administration into labeling guidelines from 1978 to 1995, fewer than 3 percent of children and less than 10 percent of adults had minor side effects, and only one or two measurements of the serum concentration were generally needed to determine the appropriate dosage.

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Also, incidental findings lead to additional medical procedures and expense that do not improve patient well-being.

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In foods and beverages, fresh garlic, garlic powder, and garlic oil are used to add flavor.

The flu vaccine is also available as a nasal spray, but according to the Centers for Disease Control and Prevention (CDC), the spray should NOT be used in people with asthma.

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Thus, administration of single Theophylline (Anhydrous) Extended-Release doses to healthy normal volunteers, under prolonged fasted conditions (at least 10 hour overnight fast before dosing followed by an additional four (4) hour fast after dosing) results in decreased bioavailability.

In one study, nearly half of asthma or allergy sufferers resorted to alternative treatments.

The Cochrane database of systematic reviews 12: CD004136.

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