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My wife had frequent leg movements throughout the night. Mirapex immediately stopped the leg movements. She continues to take the drug daily and restless leg syndrome has not returned. Very effective drug.
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In the University of Rochester study, the first patients monthlong break from a dopamine agonist helped the drug to be effective again for four more months before her symptoms came back.

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Pramipexole total oral clearance was approximately 30% lower in subjects older than 65 years compared with younger subjects, because of a decline in pramipexole renal clearance due to an age-related reduction in renal function.

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Just went to neurologist today and he said it sounds like the medicine has augmented my RLS, made it worse, and wants to wean me off as soon as possible.

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