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During this trial, the percentages in whom antinuclear antibodies and antibodies against double-stranded DNA developed were significantly higher in the groups given infliximab plus methotrexate than in the group given methotrexate alone ().
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Although a large proportion of patients in the MTX and placebo group also did not need biologic therapy during the first 2 years of their disease, patients in the MTX and placebo strategy had a slower clinical response and less favorable outcome on all variables than those in the MTX and prednisone group, including physical functioning and quality of life.
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